Contents

1. Alzheimer’s Disease related Signalling Pathways 

       1.1. Neuroinflammation in Alzheimer’s Disease 

       1.2. Oxidative Stress and Alzheimer’s Disease

 

2. AMP-Activated Protein Kinase (AMPK)

       2.1. Noncanonical Activation of AMPK

 

3. Apoptosis

      3.1 Apoptosis Mechanisms

      3.2. Biochemical Features

      3.3. Extrinsic Pathway

      3.4. Granzyme A and B

      3.5. Intrinsic Pathway

     

4. Autophagy

      4.1. Molecular Mechanism of Autophagy

      4.2. Mitophagy

 

5. Cell Death Through Necrosis

      5.1. Necroptosis Molecular Mechanism

      5.2. Pyroptosis

      

6. Cellular Senescence

 

7. DNA Methylation

       7.1. DNA Methylation

       7.2. DNA Methylation and Histone Modifications

       7.3. DNA Demethylation

       7.4. DNA Methylation in Cancer

 

8. G2/DNA Damage Checkpoint

      8.1. G2/DNA Damage Checkpoint Overview

      8.2. ChK1 Stimulation and Mechanism of Termination of Chk1 Mediated Signal

 

9. Histone Methylation

       9.1. Histone Modifications and Chromatin

       9.2. Histone Methylation and Su(var)

       9.3. Histone Methylation a Permanent Mark or Not?

 

10. Hypoxia Signalling

  

11. Insulin Receptors

       11.1. PIP3 and PI3K and Related Downstream Pathway

 

12. Metabolic Pathways of Glutamine

 

13. mTORC Signalling

       13.1. mTORC1 Signalling

       13.2. mTORC2 Signalling

 

14. N-methyl-D-aspartate receptors (NMDARs)

       14.1. NMDAR Signalling Pathway

       14.2. Glycine Binding Role in NMDAR Signalling

       14.3. Glutamate Binding Role in NMDAR Signalling

 

15. Parkinson’s Disease Related Signalling Pathways

       15.1. Dopaminergic Neurodegeneration Facilitated Throug G2019S-LRRK2 is Relied on Kinase or Action by GTPases

       15.2. Dopaminergic Neurons and ERK Signalling

 

16. Protein Acetylation

       16.1. Histone Acetylation and Deacetylation

       16.2. Non-Histone Protein Acetylation and Deacetylation

       16.3. Protein Acetylation and Deacetylation

 

 17. The Warburg Effect

       17.1. The Regulatory Elimination of The Oxidative Metabolism in Cancer 

       17.2. The Genes That Play Role in The Warburg Effect

 

 18. TREM2 Signalling Pathway

 

 I was inspired by Cell Signalling Technology https://www.cellsignal.co.uk in producing this body of work